San Francisco's 2025 draft class is taking shape as Week 2 shows real growth from Mykel Williams and Alfred Collins. Kyle Shanahan praised their improved play, noting Williams’ three QB pressures and four run stops and Collins’ QB hit after a double team. The duo’s steady progress fuels the 49ers’ defensive depth and keeps the Super Bowl window open, though continued development remains essential.

For fantasy managers, the Week 2 uptick hints at late-season upside in a rotation that could drive consistent DL opportunities and pressure-based scoring. If Williams and Collins sustain this trajectory, the 49ers’ front could anchor a top-tier unit and unlock higher-floor fantasy days as the season unfolds.

Brady and Payton team up for a 2026 Saudi flag football showcase, signaling a bold push to grow the game globally. Brady’s Raiders minority ownership and headset in the Raiders booth add a fresh cross-team dynamic that could influence narratives around divisional matchups.

Denver hosts Las Vegas on Nov. 6 and visits Dec. 7 as schedules shape the storyline. With Brady's Fox work uncertain, the immediate fantasy impact is narrative-driven, not a wholesale shift in efficiency—yet the Brady-Payton axis deserves a closer watch for late-season betting angles.

Arizona hosts San Francisco in Week 3 with a crowded injury report. Will Johnson DNP groin; Melton limited with a knee; Beachum, Hernandez, Paris Johnson Jr, Reiman, Simon and Stills limited or resting concerns; Jordan James back to full participation with a finger issue. The Cardinals eye a 3-0 start while juggling depth and playmakers.

San Francisco faces a similar test with eight DNPs on the list but Brock Purdy back in limited action as he finishes toe and shoulder rehab. With Nick Bosa resting and Christian McCaffrey dealing with a calf/rest, Kyle Shanahan will lean on creative wrinkles. Kyler Murray notes Levi’s Stadium vibe as a factor in this NFC West clash.